The inhibitory effect of gourami fish scale (Osphronemus gouramy) extract-curcumin combination on Porphyromonas gingivalis

Background: Gourami fish scales, often considered as a waste, turned out to be an alternative source for antibacterial components. Its extract contains alkaloid, agent, while also hydrogen bonds which have the effect of increasing interaction with other substances. Curcumin is one active ingredients turmeric, spice commonly used herbal medicine in Indonesia. could suppress bacterial proliferation by inhibiting virulence agents. The combination these substances was expected help inhibit Porphyromonas gingivalis growth, key pathogens periodontitis patients. Objective: This study aims determine inhibitory gourami scale extract-curcumin on growth P. bacteria. Method: research vitro experimental analytical laboratory research. concentrations are 100%; 50%; 25%; 12.5%; 6.25%; 3.125%; 1.56%; and 0.78%. inhibition testing bacteria cultures carried spectrophotometric methods colony counts. Results: concentration 100% killed colonies resulting 0 colonies. A 6.25% inhibits 92.9%. statistical test result showed significant difference (p < 0.05). Conclusion: has MIC value at MBC 12.5%.